Core FLEX Powder

Full Science

Physiological Properties and Effects:

Celadrin®

Celadrin® is a patented and proprietary mixture of esterfied fatty acid carbons, also known as cetylated fatty acids.

Celadrin® is the subject of multiple clinical trials, assessing its efficacy in pain and inflammation reduction, quality of life improvements, and range of motion improvements in patients with osteoarthritis. In a 2004 study, for example, 40 subjects with confirmed knee osteoarthritis were measured for performance in simple mobility tests before, during, and after challenge with Celadrin. The researchers in this study noted significant improvement for the control group in all tested metrics, while the placebo group did not display statistically significant changes.

The compound was studied again in 2005 on two occasions and found to exert significant effects on mobility and perception of pain in subjects with osteoarthritis. Across the two studies, comprising 58 total subjects, and assessment time of 30 days each, Celadrin® was found to increase postural stability and functional mobility (across a variety of measures). Additionally, Celadrin displayed significant effects in reducing the subjective perception of pain according to a standardized pain measure and subject self-reporting.

Chondroitin and Glucosamine:

Chondroitin and Glucosamine are substances found naturally in the body, and in particular, in and around the cartilage and other connective tissues. Glucosamine falls within a class of compounds known as amino sugar, and is a precursor to a molecule called glycosaminoglycan. The human body produces and distributes both of these compounds as critical components in the production of cartilage and other connective tissue . It also aids in lubricating and providing thickness to the cartilage around damaged joints. Chondroitin sulfate is a type of glycosaminoglycan and complex carbohydrate rich in sulfur, and is a relative of glucosamine. Chondroitin is one of the major constituents of cartilage, not only providing structure and stability, but also water for the purpose of lubrication.

Methylsulfonylmethane (MSM):

MSM is a naturally occurring, organosulfur molecule that can be synthesized both naturally and synthetically from DSMO. While the majority of MSM present in the human body is ingested – either deliberately or accidentally – the compound does have a natural presence in certain tissues and fluids in the body, including cerebrospinal fluid. MSM appears to assist healthy biochemical communication between cells that may assist joint flexibility and mobility. While still emerging, certain data on MSM appears to show a promising role for the compound in the maintenance of proper joint function. Several studies demonstrate joint function increases on the WOMAC scale ranging from 20-35%, while animal data suggests equally significant results. Though not every trial on MSM reveals such significant results, a meta-analysis conducted in 2011 found that the overwhelming majority of clinical MSM trials featured function improvements over placebo.

Cissus quadrangularis (stem) (10% ketosterones):

Cissus quadrangularis (CQ) is a plant with a long history of use in traditional and folk medicinal systems, including thousands of years of documented use in the Siddha and Ayurvedic traditions. While the specific use of Cissus in these systems varied, the most common traditional preparations related to analgesia, general tonics, and bone fracture healing. More recent research has developed physiological explanations for CQ’s traditional efficacy, including the reduction of pro-inflammatory cytokines, modulation of the glucocorticoid system (in animal trials), and the proliferation of osteoblast (bone-forming cell) DNA.

Specific to bone formation, there is strong data to suggest that CQ increases the accumulation of compounds known as mucopolysaccharides – long chain sugar molecules that precede mineralization in the process of bone formation. Think of these compounds sort of like the wet newspaper before it becomes paper mache. As stated, separate research also suggests that extracts of CQ stimulated osteoblastogenesis, the process of forming bone cells.

Boswellia Extract (Boswellia serrata) (gum resin) (37% Boswellic Acid):

Boswellia is a tree resin extract that is a traditional part of Indian medicine. In modern clinical trials the active agenct, boswellic acid, has been found to inhibit the production of pro-inflammatory leukotrienes. Similarly to curcumin, boswellic acids have demonstrated a significant attenuation of NF-kB production in various animal and in vitro assays.

Bromelain (2400 GDU/g) (from pineapple):

Bromelain is a collection of protein-digesting enzymes found in pineapple juice and in the stem of pineapple plants. It has been shown to have a myriad of health benefits including speed of recovery, antioxidant properties, and assisting cardiovascular and circulatory health. The mechanism of the anti-inflammatory activity is not very well understood, but like curcumin and boswellia it appears to support inflammatory marker balance. Numerous studies have shown bromelain’s ability to assist and speed recovery time following various health related procedures.

Black Cherry Extract (Prunus serotina) (fruit) (4:1):

Black cherry extract contains a number of beneficial compounds, including high levels of anthocyanin – an extremely potent anti-inflammatory compound which some animal evidence has shown plays a role in the maintenance of articular jointsIt is rich in antioxidants and catechins, chlorogenic acid, and flavonal glycoside, and has been used to support healthy uric acid levels typically associated with complete joint health.

Vitamin C:

Vitamin C is not only a powerful antioxidant, but also supports a healthy immune system, protects cells from oxidized particles and free radicals, and assists other physiological functions. A major study by the University of California at Berkeley found that supplementing with 500 milligrams of Vitamin C (the daily serving contained in Core FLEX) led to a 24% reduction in levels of C-reactive protein, a consistent marker of inflammation. In conjunction with the other ingredients, it is important component of strong joints and overall health.

Vitamin D3:

Vitamin D3 is an essential hormone precursor that plays a vital role in many metabolic functions, including bone health, , immune and cardiovascular health, muscle protein synthesis, and weight management. Although some foods contain Vitamin D3, the human body generates most of its Vitamin D3 needs from the skin through regular exposure to sunlight. Healthy and normal Vitamin D3 levels are essential to maintaining numerous bodily processes, including regulating the pro-inflammatory responses of joints and connective tissues to damage.